CanVIG-UK Resources

CanVIG-UK Summary Variant List (live sync)

A summary list of variants previously classified by the CanVIG-UK group or currently in progress. For full consensus classifications, please see CanVar-UK or ClinVar.

Please note; variant review by CanVIG-UK is limited to variants dictated by members as pertinent to the development of cancer variant interpretation guidance. At this time, we do not have the capacity to formally review variants outside this remit. 

PHE: BRCA1/BRCA2 Insertion, Deletion and Duplication Variants 

Downloadable excel sheet of BRCA1/BRCA2 insertion, deletion, duplication and insertion-deletion variants returned by Public Health England (PHE) as part of UK clinical laboratory data collection.

Release date: May 2020

Report Template: Pathogenic/Likely Pathogenic Variant Detected

Example template for reporting a BRCA1 germline pathogenic/likely pathogenic variant.

Approved: July 2020

Report Template: Variant of Uncertain Significance Detected

Example template for reporting a BRCA1 germline variant of uncertain significance.

Approved: July 2020

Report Template: No Pathogenic Variant Detected

Example template for reporting no germline pathogenic variants detected.

Approved: July 2020

Blank Variant Classification Sheet (Pre-meeting Excel)

Downloadable excel sheet for individuals to classify the variant of the month prior to discussion at the CanVIG-UK monthly meeting.

Presentation: BA1 and BS1 for Lynch and PALB2

Presenter: Miranda Durkie

Meeting date: Friday 9 October 2020

Presentation: BA1 and BS1 for BRCA1 and BRCA2

Presenter: Miranda Durkie

Meeting date: Friday 9 October 2020

Presentation: Functional Characterisation of BRCA1 Variants

(Bouwman et al., 2020)

Presenter: George Burghel

Meeting date: Friday 8 January 2021

Presentation: Evaluation of Functional Studies

(Brnich et al., 2020)

Presenter: George Burghel

Meeting date: Friday 13 December 2019

Presentation: PVS1 / PM4 case studies

Presenter: James Drummond

Meeting date: Friday 13 November 2020