CanVIG-UK Resources

CanVIG-UK Summary Variant List (live sync)

A summary list of variants previously classified by the CanVIG-UK group or currently in progress. For full consensus classifications, please see CanVar-UK or ClinVar.

Please note; variant review by CanVIG-UK is limited to variants dictated by members as pertinent to the development of cancer variant interpretation guidance. At this time, we do not have the capacity to formally review variants outside this remit. 

PHE: CRC/BRCA1/BRCA2 Insertion, Deletion and Duplication Variants 

Downloadable excel sheet of insertion, deletion, duplication and insertion-deletion variants returned by Public Health England (PHE) as part of UK clinical laboratory data collection. Includes key CRC genes as well as BRCA1/BRCA2.

Release date: July 2021

Report Template: Pathogenic/Likely Pathogenic Variant Detected
*NEW VERSION 2.0*

Example template for reporting a BRCA1 germline pathogenic/likely pathogenic variant.

Approved: June 2021

Report Template: Positive for Pathogenic Variant (Predictive)
*NEW VERSION 2.0*

Example template for reporting a positive BRCA pathogenic/likely pathogenic variant in predictive testing.

Approved: June 2021

Report Template: Male BRCA1/PALB2 Positive for Pathogenic Variant (Predictive)
*NEW DOCUMENT*

Example template for reporting a positive BRCA1/PALB2 pathogenic/likely pathogenic variant in predictive testing.

Approved: June 2021

Report Template: Male BRCA2 Positive for Pathogenic Variant (Predictive)
*NEW VERSION 2.0*

Example template for reporting a positive BRCA2 pathogenic/likely pathogenic variant in predictive testing.

Approved: June 2021

Report Template: Pathogenic/Likely Pathogenic Variant Detected (Ovarian Cancer)
*NEW VERSION 2.0*

Example template for reporting a pathogenic/likely pathogenic variant in ovarian cancer.

Approved: June 2021

Report Template: Variant of Uncertain Significance Detected
 

Example template for reporting a BRCA1 germline variant of uncertain significance.

Approved: June 2021

Report Template: No Pathogenic Variant Detected
 

Example template for reporting no BRCA germline pathogenic variants detected.

Approved: June 2021

Report Template: No Pathogenic Variant Detected (Predictive Test)
 

Example template for reporting no BRCA germline pathogenic variants detected when performing a predictive test.

Approved: June 2021

Blank Variant Classification Sheet (Pre-meeting Excel)

Downloadable excel sheet for individuals to classify the variant of the month prior to discussion at the CanVIG-UK monthly meeting.

Presentation: Multifactorial Classification Systems

Presenter: Clare Turnbull

Meeting date: Friday 9 April 2021

Presentation: BA1 and BS1 for Lynch and PALB2

Presenter: Miranda Durkie

Meeting date: Friday 9 October 2020

Presentation: BA1 and BS1 for BRCA1 and BRCA2

Presenter: Miranda Durkie

Meeting date: Friday 9 October 2020

Presentation: Functional Characterisation of BRCA1 Variants

(Bouwman et al., 2020)

Presenter: George Burghel

Meeting date: Friday 8 January 2021

Presentation: Evaluation of Functional Studies

(Brnich et al., 2020)

Presenter: George Burghel

Meeting date: Friday 13 December 2019

Presentation: PVS1 / PM4 case studies

Presenter: James Drummond

Meeting date: Friday 13 November 2020

Presentation: Variant Reinterpretation and Reclassification
 

Presenter: Lucy Loong

Meeting date: Friday 11 June 2021

Presentation: Clinical considerations of variant reclassification
 

Presenter: Helen Hanson and Miranda Durkie

Meeting date: Friday 11 June 2021

Presentation: Clinical likelihood ratios and balanced accuracy for 44 in-silico tools
*NEW DOCUMENT*

Presenter: Clare Turnbull

Meeting date: Friday 09 July 2021